Selected article for: "antigen delivery and immune response"
Author: Watanabe, Yasunori; Mendonça, Luiza; Allen, Elizabeth R.; Howe, Andrew; Lee, Mercede; Allen, Joel D.; Chawla, Himanshi; Pulido, David; Donnellan, Francesca; Davies, Hannah; Ulaszewska, Marta; Belij-Rammerstorfer, Sandra; Morris, Susan; Krebs, Anna-Sophia; Dejnirattisai, Wanwisa; Mongkolsapaya, Juthathip; Supasa, Piyada; Screaton, Gavin R.; Green, Catherine M.; Lambe, Teresa; Zhang, Peijun; Gilbert, Sarah C.; Crispin, Max
Title: Native-like SARS-CoV-2 Spike Glycoprotein Expressed by ChAdOx1 nCoV-19/AZD1222 Vaccine
  • Cord-id: 3724854p
  • Document date: 2021_4_2
    • ID: 3724854p
    Snippet: [Image: see text] Vaccine development against the SARS-CoV-2 virus focuses on the principal target of the neutralizing immune response, the spike (S) glycoprotein. Adenovirus-vectored vaccines offer an effective platform for the delivery of viral antigen, but it is important for the generation of neutralizing antibodies that they produce appropriately processed and assembled viral antigen that mimics that observed on the SARS-CoV-2 virus. Here, we describe the structure, conformation, and glycos
    Document: [Image: see text] Vaccine development against the SARS-CoV-2 virus focuses on the principal target of the neutralizing immune response, the spike (S) glycoprotein. Adenovirus-vectored vaccines offer an effective platform for the delivery of viral antigen, but it is important for the generation of neutralizing antibodies that they produce appropriately processed and assembled viral antigen that mimics that observed on the SARS-CoV-2 virus. Here, we describe the structure, conformation, and glycosylation of the S protein derived from the adenovirus-vectored ChAdOx1 nCoV-19/AZD1222 vaccine. We demonstrate native-like post-translational processing and assembly, and reveal the expression of S proteins on the surface of cells adopting the trimeric prefusion conformation. The data presented here confirm the use of ChAdOx1 adenovirus vectors as a leading platform technology for SARS-CoV-2 vaccines.

    Search related documents:
    Co phrase search for related documents
    • acid residue and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
    • acid residue and lysis buffer: 1
    • actual sars virus and acute respiratory syndrome: 1, 2, 3
    • acute respiratory syndrome and additional evidence: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
    • acute respiratory syndrome and adenovirus infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
    • acute respiratory syndrome and adenovirus receptor: 1, 2
    • acute respiratory syndrome and low abundance: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • acute respiratory syndrome and lymph node: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35
    • acute respiratory syndrome and lymph node germinal center: 1
    • acute respiratory syndrome and lysis buffer: 1, 2, 3