Author: Maximilian F Konig; Mike Powell; Verena Staedtke; Ren-Yuan Bai; David L Thomas; Nicole Fischer; Sakibul Huq; Adham M Khalafallah; Allison Koenecke; Nickolas Papadopoulos; Kenneth W Kinzler; Bert Vogelstein; Joshua T Vogelstein; Susan Athey; Shibin Zhou; Chetan Bettegowda
Title: Targeting the catecholamine-cytokine axis to prevent SARS-CoV-2 cytokine storm syndrome Document date: 2020_4_8
ID: 0lwmzjxz_5
Snippet: To date, no controlled trials have examined the potential benefits of âº1-AR antagonism for the prevention of CSS and mitigation of ARDS in human subjects. To investigate a role for âº1-AR antagonists in preventing poor outcomes resulting from pulmonary hyperinflammatory responses, we conducted a retrospective analysis of two cohorts of 45-64 year-old hospitalized patients from the MarketScan Research Database (2007 Database ( -2015 . Some of t.....
Document: To date, no controlled trials have examined the potential benefits of âº1-AR antagonism for the prevention of CSS and mitigation of ARDS in human subjects. To investigate a role for âº1-AR antagonists in preventing poor outcomes resulting from pulmonary hyperinflammatory responses, we conducted a retrospective analysis of two cohorts of 45-64 year-old hospitalized patients from the MarketScan Research Database (2007 Database ( -2015 . Some of these patients would be expected to be taking âº1-AR antagonists for the treatment of chronic conditions unrelated to ARDS such as benign prostatic hyperplasia or hypertension.
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