Author: Kumari G. Lokugamage; Adam Hage; Craig Schindewolf; Ricardo Rajsbaum; Vineet D. Menachery
Title: SARS-CoV-2 is sensitive to type I interferon pretreatment Document date: 2020_3_9
ID: 2w0zr9c0_20
Snippet: To explore differences in IFN-I antagonism between SARS-CoV and SARS-CoV, we examined 105 both STAT1 activation and IFN stimulated gene (ISG) expression following IFN pretreatment 106 and infection. Examining Vero cell protein lysates, we found that IFN-I treated cells infected with 107 SARS-CoV-2 induced phosphorylated STAT-1 by 48 hours post infection (Fig. 2) . STAT1 108 phosphorylation was absent in untreated cells infected with SARS-CoV-2 an.....
Document: To explore differences in IFN-I antagonism between SARS-CoV and SARS-CoV, we examined 105 both STAT1 activation and IFN stimulated gene (ISG) expression following IFN pretreatment 106 and infection. Examining Vero cell protein lysates, we found that IFN-I treated cells infected with 107 SARS-CoV-2 induced phosphorylated STAT-1 by 48 hours post infection (Fig. 2) . STAT1 108 phosphorylation was absent in untreated cells infected with SARS-CoV-2 and suggest the novel 109
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