Author: Kumari G. Lokugamage; Adam Hage; Craig Schindewolf; Ricardo Rajsbaum; Vineet D. Menachery
Title: SARS-CoV-2 is sensitive to type I interferon pretreatment Document date: 2020_3_9
ID: 2w0zr9c0_42
Snippet: can be protective in mice (44); importantly, the same study found that late type I IFN induction 245 can be detrimental for MERS-CoV disease (44). Similarly, early reports have described 246 treatments using type I IFN in combination for SARS-CoV-2 infection; yet the efficacy of these 247 treatments and the parameters of their use are not known (45). Overall, sensitivity data suggest 248 that type I IFN treatment may have utility for treating SAR.....
Document: can be protective in mice (44); importantly, the same study found that late type I IFN induction 245 can be detrimental for MERS-CoV disease (44). Similarly, early reports have described 246 treatments using type I IFN in combination for SARS-CoV-2 infection; yet the efficacy of these 247 treatments and the parameters of their use are not known (45). Overall, sensitivity data suggest 248 that type I IFN treatment may have utility for treating SARS-CoV-2 if the appropriate parameters 249
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