Author: Kumari G. Lokugamage; Adam Hage; Craig Schindewolf; Ricardo Rajsbaum; Vineet D. Menachery
Title: SARS-CoV-2 is sensitive to type I interferon pretreatment Document date: 2020_3_9
ID: 2w0zr9c0_9
Snippet: The host Innate immune response is initiated when viral products are recognized by host 54 cell pattern recognition receptors, including Toll-like receptors (TLRs) and RIG-I-like receptors 55 (RLRs) (14, 15) . This response ultimately results in production of IFN-I and other cytokines, 56 which together are essential for an effective antiviral response (16). IFN-I then triggers its own 57 signaling cascade via its receptor, in autocrine or paracr.....
Document: The host Innate immune response is initiated when viral products are recognized by host 54 cell pattern recognition receptors, including Toll-like receptors (TLRs) and RIG-I-like receptors 55 (RLRs) (14, 15) . This response ultimately results in production of IFN-I and other cytokines, 56 which together are essential for an effective antiviral response (16). IFN-I then triggers its own 57 signaling cascade via its receptor, in autocrine or paracrine manner, which induces 58 phosphorylation of signal transducers and activators of transcription 1 (STAT1) and STAT2. 59
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