Author: Claude Pasquier; Alain Robichon
Title: SARS-CoV-2 might manipulate against its host the immunity RNAi/Dicer/Ago system Does mitochondria collapse upon COVID-19 infection? Document date: 2020_4_9
ID: 7g8dmz57_13
Snippet: HCoV-OC43). The same methodology for hybrid RNA duplex search was applied. Results are shown in Tables 2-5 and supplemental Table S1 . We notice that each strain presents a unique set of sequences of 20 bases length matching in reverse complement with human transcripts. These unique sets of matches present no overlapping sequences between each other. Remarkably, SARS-CoV mostly targets ncRNAs ( Table 2 and supplemental Table S1 ).MERS targets an .....
Document: HCoV-OC43). The same methodology for hybrid RNA duplex search was applied. Results are shown in Tables 2-5 and supplemental Table S1 . We notice that each strain presents a unique set of sequences of 20 bases length matching in reverse complement with human transcripts. These unique sets of matches present no overlapping sequences between each other. Remarkably, SARS-CoV mostly targets ncRNAs ( Table 2 and supplemental Table S1 ).MERS targets an histone methyltransferase (KMT2C) and a miscRNA included in this gene; a small GTPase of the Rhosubfamily that controls cellular functions like cell morphology, migration and endocytosis (CDC42); an ubiquitin protein ligase (ARH1); a calcium activated chloride channels (ANO9); a voltage and calcium-sensitive potassium channel (KCNMA1) and finally an adhesion glycoprotein that mediates cell-to-cell interactions (THBS3) ( Table 3 and supplemental Table S1 ).
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