Author: Maximilian Krause; Adnan M. Niazi; Kornel Labun; Yamila N. Torres Cleuren; Florian S. Müller; Eivind Valen
Title: tailfindr: Alignment-free poly(A) length measurement for Oxford Nanopore RNA and DNA sequencing Document date: 2019_3_25
ID: cq7g8azh_9
Snippet: Polyadenylation at the 3'-end is understood to be a major regulator of mRNA [1] [2] [3] [4] . While the poly(A) length of mRNAs has been under investigation since the 1970's [36] [37] [38] [39] , transcriptome-wide analysis of poly(A) tail lengths have only recently emerged. The advent of Oxford Nanopore Technologies (ONT) native RNA Sequencing technology now allows direct sequencing of full-length mRNA molecules, which intrinsically contain thei.....
Document: Polyadenylation at the 3'-end is understood to be a major regulator of mRNA [1] [2] [3] [4] . While the poly(A) length of mRNAs has been under investigation since the 1970's [36] [37] [38] [39] , transcriptome-wide analysis of poly(A) tail lengths have only recently emerged. The advent of Oxford Nanopore Technologies (ONT) native RNA Sequencing technology now allows direct sequencing of full-length mRNA molecules, which intrinsically contain their full poly(A) tail, unbiased by potential amplification artefacts [29] . However, even the most recent updates in basecalling tools do not perform well over long homopolymeric sequence stretches [31, 35] .
Search related documents:
Co phrase search for related documents- direct sequencing and Sequencing technology: 1, 2, 3, 4, 5, 6, 7
- direct sequencing and tail length: 1, 2
- length mrna molecule and mrna molecule: 1, 2
- mRNAs length and tail length: 1
Co phrase search for related documents, hyperlinks ordered by date