Selected article for: "cell type gene expression and gene expression"
Author: Allen Wang; Joshua A Chiou; Olivier B Poirion; Justin Buchanan; Michael J Valdez; Jamie M Verheyden; Xiaomeng Hou; Minzhe Guo; Jacklyn M Newsome; Parul Kudtarkar; Dina A Faddah; Kai Zhang; Randee E Young; Justinn Barr; Ravi Misra; Heidie Huyck; Lisa Rogers; Cory Poole; Jeffery A Whitsett; Gloria Pryhuber; Yan Xu; Kyle J Gaulton; Sebastian Preissl; Xin Sun
Title: Single Nucleus Multiomic Profiling Reveals Age-Dynamic Regulation of Host Genes Associated with SARS-CoV-2 Infection
  • Document date: 2020_4_14
    • ID: 5kvq6jtx_32
    Snippet: In this study, we focused on the lung, the organ at the center of COVID-19 morbidity 448 and mortality. We generated a snATAC-seq reference dataset of the healthy human lung 449 at three postnatal stages, and in parallel generated snRNA-seq data from the same 450 samples to allow comparison with gene expression. Importantly, datasets were produced 451 using uniform tissue procurement and single nucleus technologies for both modalities 452 across .....
    Document: In this study, we focused on the lung, the organ at the center of COVID-19 morbidity 448 and mortality. We generated a snATAC-seq reference dataset of the healthy human lung 449 at three postnatal stages, and in parallel generated snRNA-seq data from the same 450 samples to allow comparison with gene expression. Importantly, datasets were produced 451 using uniform tissue procurement and single nucleus technologies for both modalities 452 across samples. This consistency allowed us to uncover age-associated dynamics in 453 gene expression and regulation. While we focus on COVID-19 related genes in this study, 454 the datasets more broadly enable in-depth analysis of cell-type resolved dynamics of 455 chromatin accessibility and gene expression in the human lung. We hope these datasets 456 will be further utilized by the community to enhance knowledge and treatment of lung 457

    Search related documents:
    Co phrase search for related documents
    • age associate and gene expression: 1
    • age associate and single nucleus: 1
    • cell type and chromatin accessibility: 1, 2, 3, 4, 5, 6
    • cell type and depth analysis: 1
    • cell type and gene expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • cell type and gene expression comparison: 1
    • cell type and healthy human lung: 1
    • cell type and human lung: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • cell type and lung focus: 1
    • cell type and reference dataset: 1, 2
    • cell type and related gene: 1, 2, 3, 4, 5, 6, 7
    • cell type and single nucleus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • cell type and snATAC seq: 1, 2, 3, 4, 5
    • chromatin accessibility and gene expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
    • chromatin accessibility and human lung: 1, 2
    • chromatin accessibility and related gene: 1
    • chromatin accessibility and single nucleus: 1, 2
    • chromatin accessibility and snATAC seq: 1, 2
    • depth analysis and related gene: 1, 2, 3