Author: Allen Wang; Joshua A Chiou; Olivier B Poirion; Justin Buchanan; Michael J Valdez; Jamie M Verheyden; Xiaomeng Hou; Minzhe Guo; Jacklyn M Newsome; Parul Kudtarkar; Dina A Faddah; Kai Zhang; Randee E Young; Justinn Barr; Ravi Misra; Heidie Huyck; Lisa Rogers; Cory Poole; Jeffery A Whitsett; Gloria Pryhuber; Yan Xu; Kyle J Gaulton; Sebastian Preissl; Xin Sun
Title: Single Nucleus Multiomic Profiling Reveals Age-Dynamic Regulation of Host Genes Associated with SARS-CoV-2 Infection Document date: 2020_4_14
ID: 5kvq6jtx_4
Snippet: and ~30 year old (30yo) (Supplementary Table 1 ). Three lungs were sampled for each 167 age group, with both males and females represented (Supplementary Table 1 ). Of the 9 168 donors, 5 were Caucasian, 1 was African American and 3 were of unknown ancestry. For 169 all samples, flash frozen biopsies from equivalent small airway regions of the lung were 170 used. Nuclei were isolated from individual biopsies and split into two pools, one for 171 .....
Document: and ~30 year old (30yo) (Supplementary Table 1 ). Three lungs were sampled for each 167 age group, with both males and females represented (Supplementary Table 1 ). Of the 9 168 donors, 5 were Caucasian, 1 was African American and 3 were of unknown ancestry. For 169 all samples, flash frozen biopsies from equivalent small airway regions of the lung were 170 used. Nuclei were isolated from individual biopsies and split into two pools, one for 171 snRNA-seq and one for snATAC-seq. For snATAC-seq, we generated technical 172 replicates for one of the 3yo donors (D032) and an additional dataset for a lung sample 173 from a 4-month-old donor (Supplementary Table 1) . 174
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