Squamous Carcinoma of the Cervix in a 15 year old with Congenital HIV: A Case Report.

Evans, Melanie; Lawson, Ashli; Jarin, Jason D; Wilson, Ellen E

BACKGROUND Human papillomavirus (HPV) is the most prevalent sexually transmitted infection (STI) worldwide. Immunocompetent hosts have intact defense mechanisms to prevent HPV infection, but immunocompromised patients are at higher risks of complications including HPV related cancers. Most of these cancers originate from high-risk HPV strains in sexually active patients. CASE Here we present a case of an immunocompromised adolescent who developed cervical cancer despite no prior sexually activity and only ever having low-risk type HPV on biopsy. SUMMARY AND CONCLUSIONS To our knowledge, this is the first case report of a cervical cancer arising from a low-risk HPV strain in an immunocompromised non-sexually active adolescent. This case highlights the importance of preventative and screening mechanisms in immunocompromised populations as they are at a higher probability of HPV related complications, even in absence of traditional risk factors.