Selected article for: "expression level and protein expression"
Author: Wei Lin; Longfei Hu; Yan Zhang; Joshua D. Ooi; Ting Meng; Peng Jin; Xiang Ding; Longkai Peng; Lei Song; Zhou Xiao; Xiang Ao; Xiangcheng Xiao; Qiaoling Zhou; Ping Xiao; Jue Fan; Yong Zhong
Title: Single-cell Analysis of ACE2 Expression in Human Kidneys and Bladders Reveals a Potential Route of 2019-nCoV Infection
  • Document date: 2020_2_18
    • ID: mm2sp48e_15
    Snippet: The 4736 cells were classified into 9 cell types, which were highly overlapped with the public data including 7 nephron specific subtypes based on the canonical marker genes (Fig 2A) . The proximal tubule (PT) (CUBN, SLC13A3, SLC22A8) were classified into proximal convoluted tubule and proximal straight tubule based on different marker expression level 14 16 . As observed in the public dataset, we observed upregulated ACE2 expressions in all prox.....
    Document: The 4736 cells were classified into 9 cell types, which were highly overlapped with the public data including 7 nephron specific subtypes based on the canonical marker genes (Fig 2A) . The proximal tubule (PT) (CUBN, SLC13A3, SLC22A8) were classified into proximal convoluted tubule and proximal straight tubule based on different marker expression level 14 16 . As observed in the public dataset, we observed upregulated ACE2 expressions in all proximal tubule cells comparing to other cell types ( Figure 2D ). Quantitatively, we found about 5%-15% of both straight and convoluted proximal tubule cells expressing ACE2. Previous immunohistochemistry analysis 17 indicated a complex spatial distribution of ACE2 protein expression, concentrated in the brush border of the proximal tubules.

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