Author: Codo, Ana Campos; Davanzo, Gustavo Gastão; Monteiro, Lauar de Brito; de Souza, Gabriela Fabiano; Muraro, Stéfanie Primon; Virgilio-da-Silva, João Victor; Prodonoff, Juliana Silveira; Carregari, Victor Corasolla; de Biagi Junior, Carlos Alberto Oliveira; Crunfli, Fernanda; Jimenez Restrepo, Jeffersson Leandro; Vendramini, Pedro Henrique; Reis-de-Oliveira, Guilherme; Bispo Dos Santos, Karina; Toledo-Teixeira, Daniel A; Parise, Pierina Lorencini; Martini, Matheus Cavalheiro; Marques, Rafael Elias; Carmo, Helison R; Borin, Alexandre; Coimbra, LaÃs Durço; Boldrini, VinÃcius O; Brunetti, Natalia S; Vieira, Andre S; Mansour, Eli; Ulaf, Raisa G; Bernardes, Ana F; Nunes, Thyago A; Ribeiro, Luciana C; Palma, Andre C; Agrela, Marcus V; Moretti, Maria Luiza; Sposito, Andrei C; Pereira, FabrÃcio BÃscaro; Velloso, Licio Augusto; Vinolo, Marco Aurélio Ramirez; Damasio, André; Proença-Módena, José Luiz; Carvalho, Robson Francisco; Mori, Marcelo A; Martins-de-Souza, Daniel; Nakaya, Helder I; Farias, Alessandro S; Moraes-Vieira, Pedro M; Bispo dos Santos, Karina; Toledo-Teixeira, Daniel A.; Carmo, Helison R.; Boldrini, VinÃcius O.; Brunetti, Natalia S.; Vieira, Andre S.; Ulaf, Raisa G.; Bernardes, Ana F.; Nunes, Thyago A.; Ribeiro, Luciana C.; Palma, Andre C.; Agrela, Marcus V.; Sposito, Andrei C.; Mori, Marcelo A.; Nakaya, Helder I.; Farias, Alessandro S.; Moraes-Vieira, Pedro M.
Title: Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis Cord-id: 4budtw8s Document date: 2020_1_1
ID: 4budtw8s
Snippet: COVID-19 can result in severe lung injury. It remained to be determined why diabetic individuals with uncontrolled glucose levels are more prone to develop the severe form of COVID-19. The molecular mechanism underlying SARS-CoV-2 infection and what determines the onset of the cytokine storm found in severe COVID-19 patients are unknown. Monocytes and macrophages are the most enriched immune cell types in the lungs of COVID-19 patients and appear to have a central role in the pathogenicity of th
Document: COVID-19 can result in severe lung injury. It remained to be determined why diabetic individuals with uncontrolled glucose levels are more prone to develop the severe form of COVID-19. The molecular mechanism underlying SARS-CoV-2 infection and what determines the onset of the cytokine storm found in severe COVID-19 patients are unknown. Monocytes and macrophages are the most enriched immune cell types in the lungs of COVID-19 patients and appear to have a central role in the pathogenicity of the disease. These cells adapt their metabolism upon infection and become highly glycolytic, which facilitates SARS-CoV-2 replication. The infection triggers mitochondrial ROS production, which induces stabilization of hypoxia-inducible factor-1α (HIF-1α) and consequently promotes glycolysis. HIF-1α-induced changes in monocyte metabolism by SARS-CoV-2 infection directly inhibit T cell response and reduce epithelial cell survival. Targeting HIF-1ɑ may have great therapeutic potential for the development of novel drugs to treat COVID-19.
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