Selected article for: "abbott roche and low disease prevalence"
Author: Nguyen, N. N.; Mutnal, M. B.; Gomez, R. R.; Pham, H. N.; Nguyen, L. T.; Koss, W.; Rao, A.; Arroliga, A. C.; Wang, L.; Wang, D.; Hua, Y.; Powell, P. R.; Chen, L.; McCormack, C.; Linz, W. J.; Mohammad, A. A.
Title: Correlation of ELISA based with random access serologic immunoassays for identifying adaptive immune response to SARS-CoV-2
  • Cord-id: 4vr4cm1s
  • Document date: 2020_7_8
    • ID: 4vr4cm1s
    Snippet: Public health emergency of SARS-CoV-2 has facilitated diagnostic testing as a related medical countermeasure against COVID-19 outbreak. Numerous serologic antibody tests have become available through an expedited federal emergency use only process. This paper highlights the analytical characteristic of an ELISA based assay by AnshLabs and three random access immunoassay (RAIA) by DiaSorin, Roche, and Abbott that have been approved for emergency use authorization (EUA), at a tertiary academic cen
    Document: Public health emergency of SARS-CoV-2 has facilitated diagnostic testing as a related medical countermeasure against COVID-19 outbreak. Numerous serologic antibody tests have become available through an expedited federal emergency use only process. This paper highlights the analytical characteristic of an ELISA based assay by AnshLabs and three random access immunoassay (RAIA) by DiaSorin, Roche, and Abbott that have been approved for emergency use authorization (EUA), at a tertiary academic center in a low disease-prevalence area. The AnshLabs gave higher estimates of sero-prevalence, over the three RAIA methods. For positive results, AnshLabs had 93.3% and 100% concordance with DiaSorin or Abbott and Roche respectively. For negative results, AnshLabs had 69.7% and 73.0% concordance with DiaSorin and Roche or Abbott respectively. All discrepant samples that were positive by AnshLabs and negative by RAIA tested positive by all-in-one step SARS-CoV-2 Total (COV2T) assay performed on the automated Siemens Advia Centaur XPT analyzer. None of these methods, however, are useful in early diagnosis of SARSCoV- 2.

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