Author: Aaron S. Mendez; Carolin Vogt; Jens Bohne; Britt A. Glaunsinger
Title: Site specific target binding controls RNA cleavage efficiency by the Kaposi’s sarcoma-associated herpesvirus endonuclease SOX Document date: 2018_5_13
ID: 298cbr1x_58
Snippet: RNA probes (3' end labeled with biotin) were synthesized from Dharmacon (GE healthcare) and HPLC and PAGE purified (See Table S2 The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/320929 doi: bioRxiv preprint located within the bridge region of SOX close to the active site. Mutations P179S and F179A are thought to disrupt RNA binding; RNA substrate is hidden for clarity. Inset s.....
Document: RNA probes (3' end labeled with biotin) were synthesized from Dharmacon (GE healthcare) and HPLC and PAGE purified (See Table S2 The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/320929 doi: bioRxiv preprint located within the bridge region of SOX close to the active site. Mutations P179S and F179A are thought to disrupt RNA binding; RNA substrate is hidden for clarity. Inset shows that residues P176 and F179 coordinate an adenine of the RNA substrate.
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