Author: Justina Jankauskaite; Brian Jiménez-García; Justas Dapkunas; Juan Fernández-Recio; Iain H. Moal
Title: SKEMPI 2.0: An updated benchmark of changes in protein-protein binding energy, kinetics and thermodynamics upon mutation Document date: 2018_6_7
ID: d0eynz67_6
Snippet: Each entry was found in the literature and manually vetted. To ensure quality, a number of stringent checks were applied. Firstly, we ensured that the structure and the paper reporting the affinities refer to the same protein in the same species, and that structural and affinity data matched in terms of cofactors, ancillary chains and post-translational modifications. For instance, we distinguish between Ras GTP and Ras GppNHp , as the nucleotide.....
Document: Each entry was found in the literature and manually vetted. To ensure quality, a number of stringent checks were applied. Firstly, we ensured that the structure and the paper reporting the affinities refer to the same protein in the same species, and that structural and affinity data matched in terms of cofactors, ancillary chains and post-translational modifications. For instance, we distinguish between Ras GTP and Ras GppNHp , as the nucleotide modulates the affinity of Ras with its effectors. Where the full length protein was not used, we checked to ensure that the fragment in the crystal structure matched that for which affinities are reported.
Search related documents:
Co phrase search for related documents- crystal structure and length protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- crystal structure and paper structure: 1, 2, 3
- crystal structure and post translational modification: 1, 2, 3, 4
Co phrase search for related documents, hyperlinks ordered by date