Author: Justina Jankauskaite; Brian Jiménez-García; Justas Dapkunas; Juan Fernández-Recio; Iain H. Moal
Title: SKEMPI 2.0: An updated benchmark of changes in protein-protein binding energy, kinetics and thermodynamics upon mutation Document date: 2018_6_7
ID: d0eynz67_8
Snippet: In addition to checking new entries, we reappraised the papers cited in SKEMPI 1.1 to collect data that were not collected previously, specifically to find mutants which abolish binding and to classify the experimental method used when not already included in the subset of SKEMPI covered in [22] . It is worth noting that often an author's decision to report an interaction of affinity below the detection threshold as either non-binding, or as less.....
Document: In addition to checking new entries, we reappraised the papers cited in SKEMPI 1.1 to collect data that were not collected previously, specifically to find mutants which abolish binding and to classify the experimental method used when not already included in the subset of SKEMPI covered in [22] . It is worth noting that often an author's decision to report an interaction of affinity below the detection threshold as either non-binding, or as less affine than the weakest affinity presented in the paper, is arbitrary. Thus, those wishing to use the non-binding data as an inequality on the affinity may do so. We also corrected entries for 5 wild-type and 4 mutant affinities identified by [22] .
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