Author: Nicholas G Davies; Petra Klepac; Yang Liu; Kiesha Prem; Mark Jit; Rosalind M Eggo
Title: Age-dependent effects in the transmission and control of COVID-19 epidemics Document date: 2020_3_27
ID: 8f76vhyz_22
Snippet: We have shown a strong age dependence in the probability of displaying clinical symptoms for COVID-19, from around 20% in under 10s, to over 70% in older adults. Given evidence of a stark age gradient in severity 8 and mortality 21, 28 , and recent studies of close follow up of children at risk of infection 16 showing that infection was frequent in all age groups, the plausibility of age-specific severity is higher than age-specific susceptibilit.....
Document: We have shown a strong age dependence in the probability of displaying clinical symptoms for COVID-19, from around 20% in under 10s, to over 70% in older adults. Given evidence of a stark age gradient in severity 8 and mortality 21, 28 , and recent studies of close follow up of children at risk of infection 16 showing that infection was frequent in all age groups, the plausibility of age-specific severity is higher than age-specific susceptibility to infection. For a number of other pathogens, there is evidence that children (except for the very youngest) have lower rates of symptomatic disease 12 and mortality 26 . For these reasons, we find that age-specific clinical fraction is more supported than age-specific susceptibility to infection.
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