Nutritional assessment and the role of preexisting inflammation with a bearing on COVID-19

Soeters, Peter B.; de Leeuw, Peter W.

Although there is consensus in the European, American, Latin-American, and Asiatic nutrition and metabolic scientific societies regarding the definition of malnutrition, this definition has not been operationalized. This means that in different countries, the risk of malnutrition on outcome cannot be adequately determined or predicted. In patients with inflammatory activity, the preexistent nutritional status is an important predictor of outcome. Malnutrition is characterized by three crucial elements: undernutrition, inflammation, and diminished function. Malnutrition in our countries as well as in countries with famine almost always is caused by varying degrees of deficient nutritional intake in combination with disease or other damaging inflammatory causes of varying severity. The female genome appears to be better equipped to survive intercurrent trauma or illness than the male one, which impacts on longevity and the ability to overcome certain infections like COVID-19 at higher ages.