Author: Lulin Zhou; Zubiao Niu; Xiaoyi Jiang; Zhengrong Zhang; You Zheng; Zhongyi Wang; Yichao Zhu; Lihua Gao; Xiaoning Wang; Qiang Sun
Title: Systemic analysis of tissue cells potentially vulnerable to SARS-CoV-2 infection by the protein-proofed single-cell RNA profiling of ACE2, TMPRSS2 and Furin proteases Document date: 2020_4_10
ID: 3btc31kj_19
Snippet: The expression of TMPRSS2 also shows a tissue-specific pattern, but is different from that of ACE2 in terms of tissue distribution ( Figure 1A , 1C, S1B and S1E). And 5 tissues co-expressing relatively high mRNA levels of TMPRSS2 and ACE2 include small intestine, colon, thyroid gland, kidney and breast. At protein level, only small intestine and kidney show co-expression. Interestingly, prostate expresses the highest TMPRSS2 mRNA but undetectable.....
Document: The expression of TMPRSS2 also shows a tissue-specific pattern, but is different from that of ACE2 in terms of tissue distribution ( Figure 1A , 1C, S1B and S1E). And 5 tissues co-expressing relatively high mRNA levels of TMPRSS2 and ACE2 include small intestine, colon, thyroid gland, kidney and breast. At protein level, only small intestine and kidney show co-expression. Interestingly, prostate expresses the highest TMPRSS2 mRNA but undetectable ACE2. These results suggest that TMPRSS2 and ACE2 are not often co-expressed in the same tissues. Notably, considerable TMPRSS2 mRNA is expressed in lung, the target tissue of SARS-CoV-2 virus, which is consistent with a promoting role of TMPRSS2 in SARS-CoV-2 infection.
Search related documents:
Co phrase search for related documents- protein level and SARS virus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50
- protein level and small intestine: 1, 2, 3, 4, 5, 6, 7, 8
- protein level and target tissue: 1, 2, 3, 4
- protein level and tissue distribution: 1
- SARS infection and small intestine: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40
- SARS infection and target tissue: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- SARS infection and tissue distribution: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20
- SARS infection and tissue express: 1, 2, 3, 4
- SARS infection and tissue specific pattern: 1, 2
- SARS virus and small intestine: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22
- SARS virus and target tissue: 1, 2, 3, 4, 5, 6, 7
- SARS virus and tissue distribution: 1, 2, 3, 4, 5
- SARS virus and tissue express: 1
- SARS virus and tissue specific pattern: 1
- small intestine and target tissue: 1
- small intestine and tissue distribution: 1, 2, 3, 4, 5, 6, 7
- small intestine and tissue express: 1
- small intestine and tissue specific pattern: 1, 2, 3
- target tissue and tissue distribution: 1, 2, 3, 4, 5, 6
Co phrase search for related documents, hyperlinks ordered by date