Selected article for: "co expression and high level"
Author: Lulin Zhou; Zubiao Niu; Xiaoyi Jiang; Zhengrong Zhang; You Zheng; Zhongyi Wang; Yichao Zhu; Lihua Gao; Xiaoning Wang; Qiang Sun
Title: Systemic analysis of tissue cells potentially vulnerable to SARS-CoV-2 infection by the protein-proofed single-cell RNA profiling of ACE2, TMPRSS2 and Furin proteases
  • Document date: 2020_4_10
    • ID: 3btc31kj_39
    Snippet: The co-expression feature of these three genes was quite dominant in the intestine, specifically in enterocytes ( Figure 5E ), more than the other ACE2-high tissues such as kidney ( Figure 5D ), testis ( Figure 5F ) and stomach ( Figure S3F ). For example, as shown in Figure 5D , though the cells in the kidney expressed ACE2, TMPRSS2 and Furin at moderate to high level, there was only a small fraction of co-expression cells. The ACE2-low liver ti.....
    Document: The co-expression feature of these three genes was quite dominant in the intestine, specifically in enterocytes ( Figure 5E ), more than the other ACE2-high tissues such as kidney ( Figure 5D ), testis ( Figure 5F ) and stomach ( Figure S3F ). For example, as shown in Figure 5D , though the cells in the kidney expressed ACE2, TMPRSS2 and Furin at moderate to high level, there was only a small fraction of co-expression cells. The ACE2-low liver tissue displayed an interesting expression pattern, while the co-expression of Furin and TMPRSS2 in the hepatocytes and cholangiocytes were remarkable, their co-expression with ACE2 were much less ( Figure 5C ), arguing against liver as a primary SARS-CoV-2 target.

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