Author: Yao, Tianâ€Tian; Qian, Jianâ€Dan; Zhu, Wenâ€Yan; Wang, Yan; Wang, Guiâ€Qiang
Title: A systematic review of lopinavir therapy for SARS coronavirus and MERS coronavirus—A possible reference for coronavirus diseaseâ€19 treatment option Cord-id: 5trqi9tp Document date: 2020_3_12
ID: 5trqi9tp
Snippet: In the past few decades, coronaviruses have risen as a global threat to public health. Currently, the outbreak of coronavirus diseaseâ€19 (COVIDâ€19) from Wuhan caused a worldwide panic. There are no specific antiviral therapies for COVIDâ€19. However, there are agents that were used during the severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) epidemics. We could learn from SARS and MERS. Lopinavir (LPV) is an effective agent that inhibits the protease activ
Document: In the past few decades, coronaviruses have risen as a global threat to public health. Currently, the outbreak of coronavirus diseaseâ€19 (COVIDâ€19) from Wuhan caused a worldwide panic. There are no specific antiviral therapies for COVIDâ€19. However, there are agents that were used during the severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) epidemics. We could learn from SARS and MERS. Lopinavir (LPV) is an effective agent that inhibits the protease activity of coronavirus. In this review, we discuss the literature on the efficacy of LPV in vitro and in vivo, especially in patients with SARS and MERS, so that we might clarify the potential for the use of LPV in patients with COVIDâ€19.
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