Author: Tsai, Keng-Chang; Chen, Shih-Yuan; Liang, Po-Huang; Lu, I-Lin; Mahindroo, Neeraj; Hsieh, Hsing-Pang; Chao, Yu-Sheng; Liu, Lincoln; Liu, Donald; Lien, Wei; Lin, Thy-Hou; Wu, Su-Ying
Title: Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies. Cord-id: 5u4u0f0l Document date: 2006_1_1
ID: 5u4u0f0l
Snippet: The severe acute respiratory syndrome-associated coronavirus (SARS-CoV) 3C-like protease (3CL(pro) or M(pro)) is an attractive target for the development of anti-SARS drugs because of its crucial role in the viral life cycle. In this study, a compound database was screened by the structure-based virtual screening approach to identify initial hits as inhibitors of SARS-CoV 3CL(pro). Out of the 59,363 compounds docked, 93 were selected for the inhibition assay, and 21 showed inhibition against SAR
Document: The severe acute respiratory syndrome-associated coronavirus (SARS-CoV) 3C-like protease (3CL(pro) or M(pro)) is an attractive target for the development of anti-SARS drugs because of its crucial role in the viral life cycle. In this study, a compound database was screened by the structure-based virtual screening approach to identify initial hits as inhibitors of SARS-CoV 3CL(pro). Out of the 59,363 compounds docked, 93 were selected for the inhibition assay, and 21 showed inhibition against SARS-CoV 3CL(pro) (IC(50)
Search related documents:
Co phrase search for related documents- Try single phrases listed below for: 1
Co phrase search for related documents, hyperlinks ordered by date