Therapeutic Potential of Alpha-Lipoic Acid in Viral Infections, including COVID-19

Dragomanova, Stela; Miteva, Simona; Nicoletti, Ferdinando; Mangano, Katia; Fagone, Paolo; Pricoco, Salvatore; Staykov, Hristian; Tancheva, Lyubka

Oxidative stress (OS), resulting from a disrupted balance between reactive oxygen species (ROS) and protective antioxidants, is thought to play an important pathogenetic role in several diseases, including viral infections. Alpha-lipoic acid (LA) is one of the most-studied and used natural compounds, as it is endowed with a well-defined antioxidant and immunomodulatory profile. Owing to these properties, LA has been tested in several chronic immunoinflammatory conditions, such as diabetic neuropathy and metabolic syndrome. In addition, a pharmacological antiviral profile of LA is emerging, that has attracted attention on the possible use of this compound for the cotreatment of several viral infections. Here, we will review the emerging literature on the potential use of LA in viral infections, including COVID-19.