Selected article for: "downregulated gene and gene overlap"
Author: Chad N. Brocker; Donghwan Kim; Tisha Melia; Kritika Karri; Thomas J. Velenosi; Shogo Takahashi; Jessica A. Bonzo; David J. Waxman; Frank J. Gonzalez
Title: Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to metabolic stress
  • Document date: 2019_6_20
    • ID: dt0b7jnu_6
    Snippet: Gm15441 transgene expression downregulated Txnip, demonstrating lncRNA-mediated gene suppression in vitro. CRIPSR/Cas9-mediated gene editing was employed to develop a Gm15441 knockout (Gm15441 LSL ) mouse model. Basal TXNIP levels in Gm15441 LSL mice were significantly elevated over wild-type mice levels, supporting Gm15441 as a negative regulator of PXR (Table S1C) . These findings are consistent with the partial functional overlap between these.....
    Document: Gm15441 transgene expression downregulated Txnip, demonstrating lncRNA-mediated gene suppression in vitro. CRIPSR/Cas9-mediated gene editing was employed to develop a Gm15441 knockout (Gm15441 LSL ) mouse model. Basal TXNIP levels in Gm15441 LSL mice were significantly elevated over wild-type mice levels, supporting Gm15441 as a negative regulator of PXR (Table S1C) . These findings are consistent with the partial functional overlap between these three xenobiotic nuclear receptors and their gene targets (Cui and Klaassen, 2016; Gonzalez et al., 2015; Wada et al., 2009) .

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