Author: Ohnuma, Kei; Haagmans, Bart L; Hatano, Ryo; Raj, V Stalin; Mou, Huihui; Iwata, Satoshi; Dang, Nam H; Bosch, Berend Jan; Morimoto, Chikao
Title: Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody. Cord-id: 6eibj2hy Document date: 2013_1_1
ID: 6eibj2hy
Snippet: We identified the domains of CD26 involved in the binding of Middle East respiratory syndrome coronavirus (MERS-CoV) using distinct clones of anti-CD26 monoclonal antibodies (MAbs). One clone, named 2F9, almost completely inhibited viral entry. The humanized anti-CD26 MAb YS110 also significantly inhibited infection. These findings indicate that both 2F9 and YS110 are potential therapeutic agents for MERS-CoV infection. YS110, in particular, is a good candidate for immediate testing as a therape
Document: We identified the domains of CD26 involved in the binding of Middle East respiratory syndrome coronavirus (MERS-CoV) using distinct clones of anti-CD26 monoclonal antibodies (MAbs). One clone, named 2F9, almost completely inhibited viral entry. The humanized anti-CD26 MAb YS110 also significantly inhibited infection. These findings indicate that both 2F9 and YS110 are potential therapeutic agents for MERS-CoV infection. YS110, in particular, is a good candidate for immediate testing as a therapeutic modality for MERS.
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