Evaluation of COVID-19 chest computed tomography: A texture analysis based on three-dimensional entropy()

Gaudêncio, Andreia S.; Vaz, Pedro G.; Hilal, Mirvana; Mahé, Guillaume; Lederlin, Mathieu; Humeau-Heurtier, Anne; Cardoso, João M.

Radiologists, and doctors in general, need relevant information for the quantification and characterization of pulmonary structures damaged by severe diseases, such as the Coronavirus disease 2019 (COVID-19). Texture-based analysis in scope of other pulmonary diseases has been used to screen, monitor, and provide valuable information for several kinds of diagnoses. To differentiate COVID-19 patients from healthy subjects and patients with other pulmonary diseases is crucial. Our goal is to quantify lung modifications in two pulmonary pathologies: COVID-19 and idiopathic pulmonary fibrosis (IPF). For this purpose, we propose the use of a three-dimensional multiscale fuzzy entropy (MFE3D) algorithm. The three groups tested (COVID-19 patients, IPF, and healthy subjects) were found to be statistically different for 9 scale factors ([Formula: see text]). A complexity index (CI) based on the sum of entropy values is used to classify healthy subjects and COVID-19 patients showing an accuracy of [Formula: see text] , a sensitivity of [Formula: see text] , and a specificity of [Formula: see text]. Moreover, 4 different machine-learning models were also used to classify the same COVID-19 dataset for comparison purposes.