Author: Bikash K. Bhandari; Paul P. Gardner; Chun Shen Lim
Title: Solubility-Weighted Index: fast and accurate prediction of protein solubility Document date: 2020_2_16
ID: 2rpr7aph_21
Snippet: Protein structural flexibility has been associated with conformal variations, functions, thermal stability, ligand binding and disordered regions (Mauno Vihinen 1987; Teague 2003; Ma 2005; Radivojac 2004; Schlessinger and Rost 2005; Yuan, Bailey, and Teasdale 2005; Yin, Li, and Li 2011) . However, the use of flexibility in solubility prediction has been overlooked although their relationship has previously been noted (Tsumoto et al. 2003) . In th.....
Document: Protein structural flexibility has been associated with conformal variations, functions, thermal stability, ligand binding and disordered regions (Mauno Vihinen 1987; Teague 2003; Ma 2005; Radivojac 2004; Schlessinger and Rost 2005; Yuan, Bailey, and Teasdale 2005; Yin, Li, and Li 2011) . However, the use of flexibility in solubility prediction has been overlooked although their relationship has previously been noted (Tsumoto et al. 2003) . In this study, we have shown that flexibility strongly correlates with solubility (Fig 3) . Based on the normalised B-factors used to compute flexibility, we have derived a new position and length independent weights to score the solubility of a given protein sequence (i.e., sequence composition based score). We call this protein solubility score as SWI.
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