Author: Vishvkarma, Rahul; Rajender, Singh
Title: Could SARSâ€CoVâ€2 affect male fertility? Cord-id: 70frjkj9 Document date: 2020_6_23
ID: 70frjkj9
Snippet: We performed this systematic review to evaluate the possibility of an impact of SARSâ€CoVâ€2 infection on male fertility. SARSâ€CoVâ€2 enters the cells with the help of ACE2; therefore, testicular expression of ACE2 was analysed from transcriptome sequencing studies and our unpublished data. Literature suggested that SARSâ€CoVâ€1 (2002â€2004 SARS) had a significant adverse impact on testicular architecture, suggesting a high possibility of the impact of SARSâ€CoVâ€2 as well. Out of two
Document: We performed this systematic review to evaluate the possibility of an impact of SARSâ€CoVâ€2 infection on male fertility. SARSâ€CoVâ€2 enters the cells with the help of ACE2; therefore, testicular expression of ACE2 was analysed from transcriptome sequencing studies and our unpublished data. Literature suggested that SARSâ€CoVâ€1 (2002â€2004 SARS) had a significant adverse impact on testicular architecture, suggesting a high possibility of the impact of SARSâ€CoVâ€2 as well. Out of two studies on semen samples from COVIDâ€19 affected patients, one reported the presence of SARSâ€CoVâ€2 in the semen samples while the other denied it, raising conflict about its presence in the semen samples and the possibility of sexual transmission. Our transcriptome sequencing studies on rat testicular germ cells showed ACE expression in rat testicular germ cells. We also found ACE2 expression in transcriptome sequencing data for human spermatozoa, corroborating its presence in the testicular germ cells. Transcriptome sequencing data from literature search revealed ACE2 expression in the germ, Sertoli and Leydig cells. The presence of ACE2 on almost all testicular cells and the report of a significant impact of previous SARS coronavirus on testes suggest that SARSâ€CoVâ€2 is highly likely to affect testicular tissue, semen parameters and male fertility.
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