Author: Ding, RuXia Wang HaiXin Zhang Li Li QianQian Liu Shuo Nie JianHui Xie LiangShu Yang Yi Wu JiaJing Qin HaiYang Huang WeiJin Wang YouChun Shen YueLei Wang HuiGuo
Title: Cross-neutralizing activity of monoclonal antibodies against N501Y mutant strain of SARS-CoV-2 Cord-id: 89csf0ux Document date: 2020_1_1
ID: 89csf0ux
Snippet: The dominant N501Y mutation in the spike protein that SARS-CoV-2 virus uses to bind to the human ACE2 receptor were found in the UK, which has aroused global concern and worried. Mutations in spike protein may, in theory, result in more infectious and spreading more easily. In order to evaluate the broad-spectrum protective effect of the monoclonal antibodies(mAbs), we compared the neutralization activities of six prepared mAbs against SARS-CoV-2 with pseudovirus neutralization assay. Only one o
Document: The dominant N501Y mutation in the spike protein that SARS-CoV-2 virus uses to bind to the human ACE2 receptor were found in the UK, which has aroused global concern and worried. Mutations in spike protein may, in theory, result in more infectious and spreading more easily. In order to evaluate the broad-spectrum protective effect of the monoclonal antibodies(mAbs), we compared the neutralization activities of six prepared mAbs against SARS-CoV-2 with pseudovirus neutralization assay. Only one of them showed a decrease of 6 folds in neutralizing activity to N501Y mutant strain, compared with the wild type strain. We should continue to monitor emergence of new variants in different regions to study their infectivity and neutralization effect.
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