Author: Jacob Kames; David Dillon Holcomb; Ofer Kimchi; Michael DiCuccio; Nobuko Hamasaki-Katagiri; Tony Wang; Anton A Komar; Aikaterini Alexaki; Chava Kimchi-Sarfaty
Title: Sequence analysis of SARS-CoV-2 genome reveals features important for vaccine design Document date: 2020_3_31
ID: 2fn25l6m_27
Snippet: Since it is a surface protein, it is under constant pressure to avoid the immune response, and as a result, it is the least conserved of the coronavirus proteins, diverging both in its amino acid and its codon usage [25] . Being under constant selective pressure could be the reason why it has been able to adapt to the host genome more than other proteins. The N protein forms the ribonucleoprotein complex with the virus RNA. In contrast to S, the .....
Document: Since it is a surface protein, it is under constant pressure to avoid the immune response, and as a result, it is the least conserved of the coronavirus proteins, diverging both in its amino acid and its codon usage [25] . Being under constant selective pressure could be the reason why it has been able to adapt to the host genome more than other proteins. The N protein forms the ribonucleoprotein complex with the virus RNA. In contrast to S, the N protein is the most conserved and stable protein among the coronavirus structural proteins. It uses mostly codon pairs with intermediate frequency; thus, it could be substantially codon pair deoptimized.
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