Selected article for: "codon pair deoptimization and pair deoptimization"
Author: Jacob Kames; David Dillon Holcomb; Ofer Kimchi; Michael DiCuccio; Nobuko Hamasaki-Katagiri; Tony Wang; Anton A Komar; Aikaterini Alexaki; Chava Kimchi-Sarfaty
Title: Sequence analysis of SARS-CoV-2 genome reveals features important for vaccine design
  • Document date: 2020_3_31
    • ID: 2fn25l6m_28
    Snippet: Our thorough codon/codon pair characterization of the SARS-CoV-2 genome has led to the identification of S and N as potential targets for codon pair deoptimization. The next obvious step is to construct the deoptimized virus and test its infectivity and ability to replicate. While testing the fitness of the virus, the strategy of selecting targets would also be tested, which could lead to better understanding of the factors that make codon pair d.....
    Document: Our thorough codon/codon pair characterization of the SARS-CoV-2 genome has led to the identification of S and N as potential targets for codon pair deoptimization. The next obvious step is to construct the deoptimized virus and test its infectivity and ability to replicate. While testing the fitness of the virus, the strategy of selecting targets would also be tested, which could lead to better understanding of the factors that make codon pair deoptimization successful in generating attenuated viruses. The risk of a new emerging virus is always present, and this has been poignantly highlighted by the current SARS-CoV-2. The current work could be used for the quick generation of a SARS-CoV-2 vaccine but also as a pipeline to facilitate vaccine development when the next virus is presented.

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