Author: Jing Liu; Sumeng Li; Jia Liu; Boyun Liang; Xiaobei Wang; Hua Wang; Wei Li; Qiaoxia Tong; Jianhua Yi; Lei Zhao; Lijuan Xiong; Chunxia Guo; Jin Tian; Jinzhuo Luo; Jinghong Yao; Ran Pang; Hui Shen; Cheng Peng; Ting Liu; Qian Zhang; Jun Wu; Ling Xu; Sihong Lu; Baoju Wang; Zhihong Weng; Chunrong Han; Huabing Zhu; Ruxia Zhou; Helong Zhou; Xiliu Chen; Pian Ye; Bin Zhu; Shengsong He; Yongwen He; Shenghua Jie; Ping Wei; Jianao Zhang; Yinping Lu; Weixian Wang; Li Zhang; Ling Li; Fengqin Zhou; Jun Wang; Ulf Dittmer; Mengji Lu; Yu Hu; Dongliang Yang; Xin Zheng
Title: Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients Document date: 2020_2_18
ID: 9xmeyrtu_30
Snippet: In summary, our study of immunological characteristics of the peripheral blood in COVID-19 patients shows that the numbers of neutrophils and T cells, especially CD8 + T cells, as well as the levels of inflammatory cytokines in the peripheral blood is dynamically correlated with the severity of the disease. To the best of our knowledge, this is the first work to describe the kinetic changes of lymphocyte subsets and cytokine profiles in COVID-19 .....
Document: In summary, our study of immunological characteristics of the peripheral blood in COVID-19 patients shows that the numbers of neutrophils and T cells, especially CD8 + T cells, as well as the levels of inflammatory cytokines in the peripheral blood is dynamically correlated with the severity of the disease. To the best of our knowledge, this is the first work to describe the kinetic changes of lymphocyte subsets and cytokine profiles in COVID-19 patients. Importantly, we identified N8R and NLR as powerful prognostic factors for early identification of severe COVID-19 cases.
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