Author: Francisca Verdugo-Paiva; Ariel Izcovich; Martin Ragusa; Gabriel Rada
Title: Lopinavir/ritonavir f?or the treatment of COVID-19: A living systematic review protocol Document date: 2020_4_17
ID: mhi6w4mr_45
Snippet: The risk of bias for each randomised trial will be assessed using the 'risk of bias' tool (RoB 2.0: a revised tool to assess risk of bias in randomised trials) [ 27 ] . We will consider the effect of assignment to the intervention for this review. Two reviewers will independently assess five domains of bias for each outcome result of all reported outcomes and time points. These five domains are: bias due to (1) the randomisation process, (2) devi.....
Document: The risk of bias for each randomised trial will be assessed using the 'risk of bias' tool (RoB 2.0: a revised tool to assess risk of bias in randomised trials) [ 27 ] . We will consider the effect of assignment to the intervention for this review. Two reviewers will independently assess five domains of bias for each outcome result of all reported outcomes and time points. These five domains are: bias due to (1) the randomisation process, (2) deviations from intended interventions (effects of assignment to interventions at baseline), (3) missing outcome data, (4) measurement of the outcome, and (5) selection of reported results. Answers to signalling questions and supporting information collectively will lead to a domain-level judgement in the form of 'Low risk of bias', 'Some concerns', or 'High risk of bias'. These domain-level judgements will inform an overall 'risk of bias' judgement for each result.
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