Author: Andrew J. McNamara; Pranav Danthi
Title: Loss of IKK subunits limits NF-?B signaling in reovirus infected cells Document date: 2019_11_15
ID: e13xm0mh_9
Snippet: Biphasic regulation of NF-κB was also previously suggested (21, 28). Our work 250 presented here provides an explanation for this phenomenon. Serotype-specific 251 capacity of reovirus to inhibit NF-κB is genetically linked to the genome segment 252 encoding the reovirus attachment protein σ1 (28). Because σ1 properties impact the 253 efficiency of infection and the level of viral gene expression (29), we think that the 254 genetic link betwe.....
Document: Biphasic regulation of NF-κB was also previously suggested (21, 28). Our work 250 presented here provides an explanation for this phenomenon. Serotype-specific 251 capacity of reovirus to inhibit NF-κB is genetically linked to the genome segment 252 encoding the reovirus attachment protein σ1 (28). Because σ1 properties impact the 253 efficiency of infection and the level of viral gene expression (29), we think that the 254 genetic link between σ1 and NF-κB is indirect and the viral factor responsible for 255 diminishment of IKK levels and blockade of NF-κB signaling remains unknown. 256 NF-κB is an effective pro-inflammatory signaling pathway that curbs infection. 257
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