Author: Colaneri, Marta; Valsecchi, Pietro; Perotti, Luciano; Ludovisi, Serena; Seminari, Elena; Chiara Pieri, Teresa; Sacchi, Paolo; Bruno, Raffaele
Title: Running out of bullets: the challenging management of acute hepatitis and SARSâ€COVâ€2 from the SMatteo COvid19 Registry (SMACORE) Cord-id: 9aj5yxkd Document date: 2020_7_17
ID: 9aj5yxkd
Snippet: Liver impairment is frequent in patients with novel coronavirus disease (COVIDâ€19) and direct viral tropism for the liver has been proven. Since several of the currently administered drugs against severe acute respiratory syndrome coronavirus 2 (SARSâ€CoVâ€2) are possibly hepatotoxic, the management of patients with COVIDâ€19 and liver failure is still an almost unexplored field. Taking this challenging case of acute HBV with persistent hyperbilirubinemia and SARSâ€COVâ€2 infection with r
Document: Liver impairment is frequent in patients with novel coronavirus disease (COVIDâ€19) and direct viral tropism for the liver has been proven. Since several of the currently administered drugs against severe acute respiratory syndrome coronavirus 2 (SARSâ€CoVâ€2) are possibly hepatotoxic, the management of patients with COVIDâ€19 and liver failure is still an almost unexplored field. Taking this challenging case of acute HBV with persistent hyperbilirubinemia and SARSâ€COVâ€2 infection with respiratory distress as a starting point, we here loop through this condition. Where the available therapeutic options are scarce, we here propose hemoperfusion (HP) as an attractive alternative to both delay any lateâ€stage progression of hyper inflammation process in COVIDâ€19 and remove the toxins involved in acute liver failure.
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