Selected article for: "human virus and non human primate"
Author: Lo, Michael K.; Jordan, Robert; Arvey, Aaron; Sudhamsu, Jawahar; Shrivastava-Ranjan, Punya; Hotard, Anne L.; Flint, Mike; McMullan, Laura K.; Siegel, Dustin; Clarke, Michael O.; Mackman, Richard L.; Hui, Hon C.; Perron, Michel; Ray, Adrian S.; Cihlar, Tomas; Nichol, Stuart T.; Spiropoulou, Christina F.
Title: GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses
  • Cord-id: 9gfgn7r1
  • Document date: 2017_3_6
    • ID: 9gfgn7r1
    Snippet: GS-5734 is a monophosphate prodrug of an adenosine nucleoside analog that showed therapeutic efficacy in a non-human primate model of Ebola virus infection. It has been administered under compassionate use to two Ebola patients, both of whom survived, and is currently in Phase 2 clinical development for treatment of Ebola virus disease. Here we report the antiviral activities of GS-5734 and the parent nucleoside analog across multiple virus families, providing evidence to support new indications
    Document: GS-5734 is a monophosphate prodrug of an adenosine nucleoside analog that showed therapeutic efficacy in a non-human primate model of Ebola virus infection. It has been administered under compassionate use to two Ebola patients, both of whom survived, and is currently in Phase 2 clinical development for treatment of Ebola virus disease. Here we report the antiviral activities of GS-5734 and the parent nucleoside analog across multiple virus families, providing evidence to support new indications for this compound against human viruses of significant public health concern.

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