Prevalence of depression and its association with quality of life in clinically stable patients with COVID-19

Ma, Yu-Fen; Li, Wen; Deng, Hai-Bao; Wang, Lei; Wang, Ying; Wang, Pei-Hong; Bo, Hai-Xin; Cao, Jing; Wang, Yu; Zhu, Li-Yun; Yang, Yuan; Cheung, Teris; Ng, Chee H.; Wu, Xinjuan; Xiang, Yu-Tao

INTRODUCTION: : High risk of mental health problems is associated with Coronavirus Disease 2019 (COVID-19). This study explored the prevalence of depressive symptoms (depression hereafter) and its relationship with quality of life (QOL) in clinically stable patients with COVID-19. METHODS: : This was an online survey conducted in COVID-19 patients across five designated isolation hospitals for COVID-19 in Hubei province, China. Depression and QOL were assessed with standardized instruments. RESULTS: : A total of 770 participants were included. The prevalence of depression was 43.1% (95%CI: 39.6%-46.6%). Binary logistic regression analysis found that having family member infected with COVID-19 (OR=1.51, P=0.01), suffering from severe COVID-19 infection (OR=1.67, P=0.03), male gender (OR=0.53, P<0.01), and frequent social media use to obtain COVID-19 related information (OR=0.65, P<0.01) were independently associated with depression. Patients with depression had lower QOL than those without. CONCLUSION: : Depression is highly prevalent in clinically stable patients with COVID-19. Regular screening and appropriate treatment of depression are urgently warranted for this population.