Selected article for: "blood cell and excessive inflammatory response"
Author: Janssen, Nico A F; Grondman, Inge; de Nooijer, Aline H; Boahen, Collins K; Koeken, Valerie A C M; Matzaraki, Vasiliki; Kumar, Vinod; He, Xuehui; Kox, Matthijs; Koenen, Hans J P M; Smeets, Ruben L; Joosten, Irma; Brüggemann, Roger J M; Kouijzer, Ilse J E; van der Hoeven, Hans G; Schouten, Jeroen A; Frenzel, Tim; Reijers, Monique; Hoefsloot, Wouter; Dofferhoff, Anton S M; van Apeldoorn, Marjan J; Blaauw, Marc J T; Veerman, Karin; Maas, Coen; Schoneveld, Arjan H; Hoefer, Imo E; Derde, Lennie P G; van Deuren, Marcel; van der Meer, Jos W M; van Crevel, Reinout; Giamarellos-Bourboulis, Evangelos J; Joosten, Leo A B; van den Heuvel, Michel M; Hoogerwerf, Jacobien; de Mast, Quirijn; Pickkers, Peter; Netea, Mihai G; van de Veerdonk, Frank L
Title: Dysregulated innate and adaptive immune responses discriminate disease severity in COVID-19
  • Cord-id: 9qhvm04f
  • Document date: 2021_2_1
    • ID: 9qhvm04f
    Snippet: The clinical spectrum of COVID-19 varies and the differences in host response characterizing this variation have not been fully elucidated. COVID-19 disease severity correlates with an excessive pro-inflammatory immune response and profound lymphopenia. Inflammatory responses according to disease severity were explored by plasma cytokine measurements and proteomics analysis in 147 COVID-19 patients. Furthermore, peripheral blood mononuclear cell cytokine production assays and whole blood flow cy
    Document: The clinical spectrum of COVID-19 varies and the differences in host response characterizing this variation have not been fully elucidated. COVID-19 disease severity correlates with an excessive pro-inflammatory immune response and profound lymphopenia. Inflammatory responses according to disease severity were explored by plasma cytokine measurements and proteomics analysis in 147 COVID-19 patients. Furthermore, peripheral blood mononuclear cell cytokine production assays and whole blood flow cytometry were performed. Results confirm a hyperinflammatory innate immune state, while highlighting hepatocyte growth factor and stem cell factor as potential biomarkers for disease severity. Clustering analysis reveals no specific inflammatory endotypes in COVID-19 patients. Functional assays reveal abrogated adaptive cytokine production (interferon-gamma, interleukin-17 and interleukin-22) and prominent T cell exhaustion in critically ill patients, whereas innate immune responses were intact or hyperresponsive. Collectively, this extensive analysis provides a comprehensive insight into the pathobiology of severe to critical COVID-19 and highlight potential biomarkers of disease severity.

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