Author: Prasanth, K. Reddisiva; Hirano, Minato; Fagg, W. Samuel; McAnarney, Eileen T.; Shan, Chao; Xie, Xuping; Hage, Adam; Pietzsch, Colette A.; Bukreyev, Alexander; Rajsbaum, Ricardo; Shi, Pei-Yong; Bedford, Mark T.; Bradrick, Shelton S.; Menachery, Vineet; Garcia-Blanco, Mariano A.
Title: Topoisomerase III-ß is required for efficient replication of positive-sense RNA viruses Cord-id: a0xfb9l4 Document date: 2020_3_27
ID: a0xfb9l4
Snippet: Based on genome-scale loss-of-function screens we discovered that Topoisomerase III-ß (TOP3B), a human topoisomerase that acts on DNA and RNA, is required for yellow fever virus and dengue virus-2 replication. Remarkably, we found that TOP3B is required for efficient replication of all positive-sense-single stranded RNA viruses tested, including SARS-CoV-2. While there are no drugs that specifically inhibit this topoisomerase, we posit that TOP3B is an attractive anti-viral target.
Document: Based on genome-scale loss-of-function screens we discovered that Topoisomerase III-ß (TOP3B), a human topoisomerase that acts on DNA and RNA, is required for yellow fever virus and dengue virus-2 replication. Remarkably, we found that TOP3B is required for efficient replication of all positive-sense-single stranded RNA viruses tested, including SARS-CoV-2. While there are no drugs that specifically inhibit this topoisomerase, we posit that TOP3B is an attractive anti-viral target.
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