Author: Dannielle Wellington; Zixi Yin; Liwei Zhang; Jessica Forbester; Kerry Kite; Henry Laurenson-Schafer; Shokouh Makvandi-Nejad; Boquan Jin; Emma Bowes; Krishnageetha Manoharan; David Maldonado-Perez; Clare Verill; Ian Humphreys; Tao Dong
Title: Low basal expression and slow induction of IFITM3 puts immune cells at risk of influenza A infection Document date: 2019_12_23
ID: ahs2wdus_3
Snippet: Influenza virus infection is highly contagious, spreading quickly among 95 individuals in a community, posing one of the greatest infectious threats to 96 modern society. Despite high infection rates, mortality rates remain lower 97 than 1% during non-pandemic years showing that the host immune system 98 can effectively clear viral infection in most cases (WHO figures) . But the very 99 young and very old are vulnerable and at higher risk of hosp.....
Document: Influenza virus infection is highly contagious, spreading quickly among 95 individuals in a community, posing one of the greatest infectious threats to 96 modern society. Despite high infection rates, mortality rates remain lower 97 than 1% during non-pandemic years showing that the host immune system 98 can effectively clear viral infection in most cases (WHO figures) . But the very 99 young and very old are vulnerable and at higher risk of hospitalisation and 100 mortality. Studies into host factors that may be important in restriction of this 101 highly pathogenic virus led to the discovery of the interferon (IFN) induced 102 trans-membrane protein 3 (IFITM3) ten years ago. 103
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