Selected article for: "cell epitope and identical epitope"

Author: Dijkstra, Johannes M.; Frenette, Aaron P.; Dixon, Brian
Title: Most Japanese individuals are genetically predisposed to recognize an immunogenic protein fragment shared between COVID-19 and common cold coronaviruses
  • Cord-id: aue8onyg
  • Document date: 2021_3_10
  • ID: aue8onyg
    Snippet: In the spring of 2020, we and others hypothesized that T cells in COVID-19 patients may recognize identical protein fragments shared between the coronaviruses of the common cold and COVID-19 and thereby confer cross-virus immune memory. Here, we look at this issue by screening studies that, since that time, have experimentally addressed COVID-19 associated T cell specificities. Currently, the identical T cell epitope shared between COVID-19 and common cold coronaviruses most convincingly identif
    Document: In the spring of 2020, we and others hypothesized that T cells in COVID-19 patients may recognize identical protein fragments shared between the coronaviruses of the common cold and COVID-19 and thereby confer cross-virus immune memory. Here, we look at this issue by screening studies that, since that time, have experimentally addressed COVID-19 associated T cell specificities. Currently, the identical T cell epitope shared between COVID-19 and common cold coronaviruses most convincingly identified as immunogenic is the CD8 (+) T cell epitope VYIGDPAQL if presented by the MHC class I allele HLA-A*24:02. The HLA-A*24:02 allele is found in the majority of Japanese individuals and several indigenous populations in Asia, Oceania, and the Americas. In combination with histories of common cold infections, HLA-A*24:02 may affect their protection from COVID-19.

    Search related documents:
    Co phrase search for related documents
    • aa stretch and acute respiratory syndrome coronavirus: 1
    • accession number and acute respiratory syndrome coronavirus: 1, 2, 3
    • accession number and low number: 1
    • accumulate number and acute respiratory syndrome coronavirus: 1