Author: Li Tan; Qi Wang; Duanyang Zhang; Jinya Ding; Qianchuan Huang; Yi-Quan Tang; Qiongshu Wang; Hongming Miao
Title: Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study Document date: 2020_3_3
ID: hhsfq8bz_17
Snippet: The copyright holder for this preprint . https://doi.org/10.1101/2020.03.01.20029074 doi: medRxiv preprint 6 To further confirm the relationship between blood LYM% and patient's condition, we increased our sample size to 12 death cases (mean age: 76 years; average therapeutic time: 20 days) (Supplementary Table 1 ). Most cases showed that LYM% was reduced to lower than 5% within 2 weeks after disease onset ( Fig. 2A) . We also randomly selected 7.....
Document: The copyright holder for this preprint . https://doi.org/10.1101/2020.03.01.20029074 doi: medRxiv preprint 6 To further confirm the relationship between blood LYM% and patient's condition, we increased our sample size to 12 death cases (mean age: 76 years; average therapeutic time: 20 days) (Supplementary Table 1 ). Most cases showed that LYM% was reduced to lower than 5% within 2 weeks after disease onset ( Fig. 2A) . We also randomly selected 7 cases (mean age: 35 years, average therapeutic time: 35 days) with severe symptoms and cured outcome (Supplementary Table 2 ) and 11 cases (mean age: 49; average therapeutic time: 26 days) with moderate symptoms and cured outcomes (Supplementary Table 3 ). LYM% of severe patients fell down initially and then rose to higher than 10% until discharged (Fig. 2B ). In contrast, LYM% of moderate patients fluctuated very little after disease onset and was higher than 20% when discharged (Fig. 2C) . These results suggest that lymphopenia is a predictor of prognosis in COVID-19 patients.
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