MO523 PATIENTS FROM COVID-19 MOSTLY RECOVER FROM TUBULAR PROTEINURIA AND ACUTE KIDNEY INJURY AFTER HOSPITAL DISCHARGE

Bouquegneau, Antoine; Huart, Justine; Lutteri, Laurence; Erpicum, Pauline; Grosch, Stéphanie; Résimont, Guillaume; Wiesen, Patricia; Thys, Marie; Rousseau, Anne-Françoise; Bovy, Christophe; Krzesinski, Jean-Marie; Lambermont, Bernard; Misset, Benoit; Pottel, Hans; Darcis, Gilles; Cavalier, Etienne; Jouret, François; Delanaye, Pierre

BACKGROUND AND AIMS: Proteinuria, hematuria and acute kidney injury (AKI) are frequently observed in hospitalized patients with COVID-19. However, few data are available on these parameters after hospital discharge. METHOD: This retrospective, observational and monocentric study included 153 hospitalized patients, in whom urine total proteinuria and α(1)-microglobulin (a marker of tubular injury) were measured. Thirty patients died. Among the 123 survivors, follow-up urine and creatinine analyses were available for 72 patients (after a median of 51 [19;93] days following hospital discharge). RESULTS: The median proteinuria at hospitalization and follow-up (n=72) was 419 [239; 748] and 79 [47; 129] mg/g, respectively (p<0.0001). The median concentrations of urinary α(1)-microglobulin (n=66) were 50 [25; 81] and 8 [0; 19] mg/g, respectively (p<0.0001). Estimating glomerular filtration rate (eGFR) was lower during the hospitalization compared to the follow-up: 81 [62; 92] versus 87 [66; 98] mL/min/1.73m² (p=0.0222). At follow-up, a decreased renal function was observed in 10/72 (14%) of patients, with 50% of them presenting decreased renal function before COVID-19 hospitalization and others developing severe AKI and/or proteinuria during hospitalization. CONCLUSION: In most hospitalized patients with COVID-19, proteinuria and eGFR significantly improved after hospital discharge. Only patients who developed severe AKI and/or heavy proteinuria will require a specific follow-up by nephrologists.