Author: Lucia Grenga; Fabrice Gallais; Olivier Pible; Jean-Charles Gaillard; Duarte Gouveia; Hélène Batina; Niza Bazaline; Sylvie Ruat; Karen Culotta; Guylaine Miotello; Stéphanie Debroas; Marie-Anne Roncato; Gérard Steinmetz; Charlotte Foissard; Anne Desplan; Béatrice Alpha-Bazin; Christine Almunia; Fabienne Gas; Laurent Bellanger; Jean Armengaud
Title: Shotgun proteomics of SARS-CoV-2 infected cells and its application to the optimisation of whole viral particle antigen production for vaccines Document date: 2020_4_17
ID: kd02dehk_26
Snippet: To evaluate to what extent virus profiles obtained by tandem mass spectrometry reflected virus production we measured SARS-CoV-2 RNA molecules by quantitative PCR analysis across the same time points ( Figure 2C ). Variations in most abundant viral protein yields reflected variation in the number of SARS-CoV-2 RNA molecules confirming that LC-MS/MS with label-free quantitation can be applied to monitor SARS-CoV-2 infection kinetics......
Document: To evaluate to what extent virus profiles obtained by tandem mass spectrometry reflected virus production we measured SARS-CoV-2 RNA molecules by quantitative PCR analysis across the same time points ( Figure 2C ). Variations in most abundant viral protein yields reflected variation in the number of SARS-CoV-2 RNA molecules confirming that LC-MS/MS with label-free quantitation can be applied to monitor SARS-CoV-2 infection kinetics.
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