Author: Courtney Mycroft-West; Dunhao Su; Stefano Elli; Scott Guimond; Gavin Miller; Jeremy Turnbull; Edwin Yates; Marco Guerrini; David Fernig; Marcelo Lima; Mark Skidmore
Title: The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding Document date: 2020_3_2
ID: 0d77ojnb_19
Snippet: Basic amino acids are known to dictate the binding between proteins and heparin. With that in mind, primary sequence analysis of the expressed protein domain and analysis of the modelled SARS-CoV-2 S1 RBD structure (Figure 3) shows that there are several potential heparin binding sites and, more importantly, that theses patches of basic amino acids are exposed on the protein surface. the author/funder. All rights reserved. No reuse allowed withou.....
Document: Basic amino acids are known to dictate the binding between proteins and heparin. With that in mind, primary sequence analysis of the expressed protein domain and analysis of the modelled SARS-CoV-2 S1 RBD structure (Figure 3) shows that there are several potential heparin binding sites and, more importantly, that theses patches of basic amino acids are exposed on the protein surface. the author/funder. All rights reserved. No reuse allowed without permission.
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