Author: Lyudmila Kovalchuke; Eugene V. Mosharov; Oren A. Levy; Lloyd A. Greene
Title: Stress-induced phospho-ubiquitin formation causes parkin degradation Document date: 2018_12_5
ID: ceepyyxj_48
Snippet: Because oxidative stress has been well-documented in PD [32] [33] [34] , we focused on the oxidative stress-dependent pathway of parkin loss. We found that, in this pathway, oxidative stress leads to PINK1-mediated ubiquitin phosphorylation, mostly of high molecular weight poly-ub conjugates. Furthermore, we found that parkin's association with phospho-Ub induced by various stressors leads to its proteasomal degradation, but not through autoubiqu.....
Document: Because oxidative stress has been well-documented in PD [32] [33] [34] , we focused on the oxidative stress-dependent pathway of parkin loss. We found that, in this pathway, oxidative stress leads to PINK1-mediated ubiquitin phosphorylation, mostly of high molecular weight poly-ub conjugates. Furthermore, we found that parkin's association with phospho-Ub induced by various stressors leads to its proteasomal degradation, but not through autoubiquitination.
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