Author: Yonghua Wu
Title: Strong evolutionary convergence of receptor-binding protein spike between COVID-19 and SARS-related coronaviruses Document date: 2020_3_4
ID: 4ihv80au_9
Snippet: To test this, we reconstructed ancestral amino acid sequences of ORF3a along internal nodes, and our results revealed 6 parallel amino acid substitutions shared between the ancestral branch leading to SARS-related CoV and the ancestral branch of COVID-19-related CoV and its sister strains (CoVZC45 and CoVZXC21) (Fig. S5 ). And we also detected a parallel amino acid substitution of ORF3a between the two ancestral branches leading to SARS-related C.....
Document: To test this, we reconstructed ancestral amino acid sequences of ORF3a along internal nodes, and our results revealed 6 parallel amino acid substitutions shared between the ancestral branch leading to SARS-related CoV and the ancestral branch of COVID-19-related CoV and its sister strains (CoVZC45 and CoVZXC21) (Fig. S5 ). And we also detected a parallel amino acid substitution of ORF3a between the two ancestral branches leading to SARS-related CoV and COVID-19-related CoV (Fig. S6 ). Considering that these evolutionary convergent branches of ORF3a also showed evolutionary convergence in spike protein as mentioned above (Fig. 1, Fig. S5 ), it may suggest that spike protein and its partner protein ORF3a may have been subjected to a co-evolutionary convergence.
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