Selected article for: "amyopathic dermatomyositis and lung disease"
Author: González-Moreno, Juan; Raya-Cruz, Manuel; Losada-Lopez, Ines; Cacheda, Ana Paula; Oliver, Cristina; Colom, Bartomeu
Title: Rapidly progressive interstitial lung disease due to anti-MDA5 antibodies without skin involvement: a case report and literature review
  • Cord-id: eo9p1rjb
  • Document date: 2018_2_7
    • ID: eo9p1rjb
    Snippet: Anti-MDA5 antibodies have been strongly associated with rapidly progressive interstitial lung disease (RP-ILD) in dermatomyositis (DM) patients, especially in the clinically amyopathic subset (CADM). We present a case of anti-MDA5 antibody-associated RP-ILD in a patient with arthritis but with no other clinical signs suggestive of DM or CADM successfully treated with a combination of cyclophosphamide, cyclosporine and corticoids. A review of the literature was also done. Despite its rarity, anti
    Document: Anti-MDA5 antibodies have been strongly associated with rapidly progressive interstitial lung disease (RP-ILD) in dermatomyositis (DM) patients, especially in the clinically amyopathic subset (CADM). We present a case of anti-MDA5 antibody-associated RP-ILD in a patient with arthritis but with no other clinical signs suggestive of DM or CADM successfully treated with a combination of cyclophosphamide, cyclosporine and corticoids. A review of the literature was also done. Despite its rarity, anti-MDA5 antibody-associated ILD should be suspected in cases of RP-ILD even without other signs of DM or CADM as prompt and aggressive treatment could improve prognosis.

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