Author: Zhou, Yuâ€Jie; Zheng, Kenneth I.; Wang, Xiaoâ€Bo; Sun, Qingâ€Feng; Pan, Keâ€Hua; Wang, Tingâ€Yao; Ma, Hongâ€Lei; Chen, Yongâ€Ping; George, Jacob; Zheng, Mingâ€Hua
Title: Metabolicâ€associated fatty liver disease is associated with severity of COVIDâ€19 Cord-id: eyx9nmnd Document date: 2020_7_5
ID: eyx9nmnd
Snippet: The Corona Virus Disease 2019 (COVIDâ€19) pandemic has attracted increasing worldwide attention. While metabolicâ€associated fatty liver disease (MAFLD) affects a quarter of world population, its impact on COVIDâ€19 severity has not been characterized. We identified 55 MAFLD patients with COVIDâ€19, who were 1:1 matched by age, sex and obesity status to nonâ€aged severe acute respiratory syndrome coronavirus 2 (SARSâ€CoVâ€2)â€infected patients without MAFLD. Our results demonstrate that
Document: The Corona Virus Disease 2019 (COVIDâ€19) pandemic has attracted increasing worldwide attention. While metabolicâ€associated fatty liver disease (MAFLD) affects a quarter of world population, its impact on COVIDâ€19 severity has not been characterized. We identified 55 MAFLD patients with COVIDâ€19, who were 1:1 matched by age, sex and obesity status to nonâ€aged severe acute respiratory syndrome coronavirus 2 (SARSâ€CoVâ€2)â€infected patients without MAFLD. Our results demonstrate that in patients aged less than 60 years with COVIDâ€19, MAFLD is associated with an approximately fourfold increase (adjusted odds ratio 4.07, 95% confidence interval 1.20â€13.79, P = .02) in the probability for severe disease, after adjusting for confounders. Healthcare professionals caring for patients with COVIDâ€19 need to be aware that there is a positive association between MAFLD and severe illness with COVIDâ€19.
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