Selected article for: "mmol ml and reaction mixture"
Author: Linlin Zhang; Daizong Lin; Yuri Kusov; Yong Nian; Qingjun Ma; Jiang Wang; Albrecht von Brunn; Pieter Leyssen; Kristina Lanko; Johan Neyts; Adriaan de Wilde; Eric J. Snijder; Hong Liu; Rolf Hilgenfeld
Title: Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication
  • Document date: 2020_2_10
    • ID: 7n8p9okf_71
    Snippet: To a solution of N-Boc-L-glutamic acid dimethyl ester (6.0 g, 21.8 mmol) in THF (60 mL) was added dropwise a solution of lithium bis(trimethylsilyl)amide (LHMDS) in THF (47 mL, 1 M) at −78°C under nitrogen. The resulting dark mixture was stirred at −78°C. Meanwhile, bromoacetonitrile (1.62 mL, 23.3 mmol) was added dropwise to the dianion solution over a period of 1 h while keeping the temperature below −70°C. The reaction mixture was sti.....
    Document: To a solution of N-Boc-L-glutamic acid dimethyl ester (6.0 g, 21.8 mmol) in THF (60 mL) was added dropwise a solution of lithium bis(trimethylsilyl)amide (LHMDS) in THF (47 mL, 1 M) at −78°C under nitrogen. The resulting dark mixture was stirred at −78°C. Meanwhile, bromoacetonitrile (1.62 mL, 23.3 mmol) was added dropwise to the dianion solution over a period of 1 h while keeping the temperature below −70°C. The reaction mixture was stirred at −78°C for additional 2 h. After the consumption of the reactant was confirmed by TLC analysis, the reaction was quenched by methanol (3 mL), and acetic acid (3 mL) in precooled THF (20 mL) was added.

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